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2-Mercaptobenzimidazole Derivatives: Synthesis and Anticonvulsant Activity

K. Anandarajagopal, Ravi N Tiwari, K.G.Bothara, J.Anbu Jeba Sunilson, C. Dineshkumar and P. Promwichit

Totally a series of 2-mercaptobenzimidazole derivatives (1A-1J) were synthesized by mannich reaction from 2-mercaptobenzimidazole by reaction with compounds having secondary amine and formaldehyde. The purity of the synthesized compounds was checked by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. Anticonvulsant activity was evaluated for newly synthesized 2- mercaptobenzimidazole derivatives by maximum electrical shock induced convulsion method. Most of the synthesized compounds exhibited highly significant anticonvulsant activity.