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A Review on Recent Advancement in Material and Manufacturing Techniques of Microneedles and Their Clinical Development

Kavita Bhagat1*, Sachin Saggar2, Anureet Kaur3, Manmeet Kaur1

A Microneedle (MNs) is an advanced technology in transdermal drug delivery system for effective and efficient delivery of vaccines and therapeutic agents. It has many advantages over conventional needles; it is non-invasive, provides painless insertion, avoid first pass metabolism etc. Microneedles are designed and fabricated by using suitable materials like silicon, metals, polymers, ceramics, etc. MNs are classified according to their mechanism of action; structure and their plane of symmetry etc. Summary of the advancement made during recent years in the clinical translation were also streamlined. This review article highlights an overview of micro needle systems, applications, classification, material selection, manufacturing methods and clinical data of MNs.