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Antidiabetic activity of methanolic extract of stem bark of Elaeodendron glaucum Pers. in Alloxanized rat model

Sweety Lanjhiyana, Debapriya Garabadu, Dheeraj Ahirwar, Papiya Bigoniya, Avtar Chand Rana, Kartik Chandra Patra, Sanjay Kumar Lanjhiyana and Murugan Karuppaih

Phytotherapy is considered to be minimum toxic or no side effects in comparison to modern allopathic medicines. Report of ethnobotany suggested that about 800 medicinal plants possess antidiabetic potential. Elaeodendron glaucum Pers. (Family/ Genus: Celastraceae; Hindi- Jamrassi, bakra; ED) is a medium sized tree which is distributed throughout India (the hotter part), Australia America, South Africa & Tropical Asia. Therefore, in this context since no extensive work has been performed for possible hypoglycemic properties of this plant, in the present experiment we have designed to standardize to total phenolic content of methanolic extract of ED (MED) and to evaluate the antidiabetic potential in normal and alloxan induced diabetic rats. Inbreed adult male Charles-Foster (CF) albino rats were used in the experiment for hypoglycemic activity in oral glucose tolerance test (OGTT) and normoglycemic rats, and antidiabetic activity in alloxan induced rats. Preliminary phytochemical screening revealed that MED showed positive response to alkaloids, saponins and triterpenes, tannins, flavonoids, carbohydrates and sterols. Further, the MED showed total phenolic content (285.2 mg/g). Results showed that the continuous post-treatment for 21 days with the MED showed potential hypoglycemic activity in OGTT and normoglycemic rats and antidiabetic activity in alloxan induced rat models. Further, isolation and establishment of exact mechanism of action of specific compound from MED is to be carried out in the future.