Appapurapu Ashok kumar, Appapurapu Anil Kumar, B.sudheer, K. Swathi and M.Vijaya Raghava Reddy
The purpose of this research was to investigate the efficiency of superdisintegrants such crosscarmellose sodium, cross povidone and sodium starch glycolate in formulating orodispersible tablets of Fluoxetine Hydrochloride tablets. Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor drug which is used in psychiatric disorder like depression. The efficiency of three super disintegrants were investigated by wet granulation and sublimation method with different concentratioins of 1.5%, 3% and 4.5%. The preformulation studies by FTIR confirmed no interactions between drug and polymers. The prepared formulations were evaluated for the pre-compression parameters & the values were within prescribed limits and indicated good free flowing properties. The tablets prepared by wet granulation & sublimation method were evaluated for physical parameters, wetting time, disintegration time, content uniformity and in vitro dissolution. The physical parameters were found to be satisfactory & within the limits. Upon comparison sublimation method was showed good results for disintegration time, wetting time & in vitro drug release studies because sublimation of camphor increases the porosity of the tablets. The tablets prepared with crospovidone at 4.5% concentration (FS-6) by sublimation method was found to be best formulation as it exhibited satisfactory physical parameters, least disintegration time (13 sec.), wetting time (10 sec.) & highest % drug release (99.5%) at 15 mins. In order to determine the mode of release, the data was fitted into various kinetic models and the optimized formulation followed first order kinetics.
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