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Cytotoxic Activity of Sulphonamide with Selenium to Decrease Raised Lipid Profile in the Treatment Hepatocarcinogenesis

Ritu Gupta, Firoz Anwar and R.L.Khosa

Aim: The aim of this study was to investigate the cytotoxic activity of sulfamethoxazole hydrochloride (30mg/kg) with Selenium in the form of sodium selenite (Na2SeO3) (4mg/kg) orally on lipid parameter in the treatment of hepatocarcinogenesis.

Materials and Methods: Wistar rats were divided into 7 groups and 6 animals in each group: Group 1control group (normal saline), Group 2 positive control (DEN), Group 3 (positive control for SMX), Group 4 (positive control for sodium selenite), Group5 (positive control for SMX + Se combination) Group 6 (post SMX + Se) (THR) Group7 (Pre SMX + Se) (PRH). Single intraperitoneal administration of chemical carcinogen diethylnitrosamine (DEN) (150 mg/ kg) in single dose elevated the levels of total cholesterol, triglycerides and the HDL level was decreased in the DENadministered animals of group 2 when compared to group 1animals.

Results: The levels of Total cholesterol and Triglycerides were significantly elevated and the serum HDL level was decreased in the DEN-administered animals of group II when compared to group 1 animals. These parameters were maintained to normal by the treatment of (SMX+SE) in the group 6, group 7 and group 5 control groups.

Conclusion: The study result suggests that at a reduced dose of combination of sulfamethoxazole and sodium selenite at doses 30mg/kg and 4mg/kg can act as chemopreventive agent in DEN induced Hepatocarcinoma.