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D-Cycloserine Augmentation of Exposure Therapy: Review and New Directions

Michelle L. Davis

Although cognitive behavioral therapy (CBT) is an efficacious intervention for anxiety disorders, there is room for improvement. Pharmacological strategies have been investigated as a means to augment CBT efficacy. One such medication, d-cycloserine (DCS), has been shown to augment extinction learning which takes place within CBT. However, the literature on DCS as an augmentative strategy for CBT for anxiety disorder treatment is mixed.