Американский журнал доставки лекарств и терапии Открытый доступ

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Design of Antibiotic Drug Loaded CarbopolCrosslinked-Poly (2-Hydroxyethylmethacrylate) Hydrogel for Wound Dressing Applications

Baljit Singh1, Ashima Sharma2, Arunima Sharma3 and Abhishek Dhiman1

Present article describes the synthesis, characterization, swelling and drug release behaviour of carbopol-cl-poly (2-hydroxyethylmethacrylate) hydrogel wound dressings. These polymers were characterized by, scanning electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy, 13C nuclear magnetic resonance spectroscopy, X-ray diffraction study, thermal degradation studies, and differential scanning calorimetry. The hydrogel film possessed smooth, homogenous surface with average surface roughness 0.570 nm. Swelling of the hydrogels increased with increase in pH of swelling medium. The hydrogel film showed 429.23 ± 33.23 % swelling in simulated wound fluid. The drug release studies showed slow drug release upto 24 h. Drug release occurred through nonFickian release mechanism and release profile of antibiotic drug moxifloxacin best followed Hixson-Crowell’s model.