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Design, Synthesis and Antimicrobial, Antifungal and Anti Inflammatory Evaluation of Some (4-Substituted Phenyl)[5 (4- Substituted Phenyl)-3-Phenyl- 4,5-Dihydro-1H-Pyrazol 1-yl]-Methanone Derivatives

Arpita R. Patel1, R. Badmanaban2, Dhrubo Jyoti Sen1 and Chhaganbhai N. Patel2

It is evident from reported articles that bacterial infections often produce pain & inflammation. In normal practice, two groups of agents (chemotherapeutics & NSAID’s) are prescribed simultaneously. Unfortunately, none of the drugs available to possesses these activities in a single molecule. Therefore, our aim is to find a compound having dual effect of anti-inflammatory & antimicrobial activitiy (twin drug concept). Pyrazole and its derivatives have been reported for these dual activities. Here an attempt has been made to synthesize eight (4-substituted phenyl)[5- (4-substituted phenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1- yl]methanone derivatives. The synthesized derivatives were assessed for their in-vitro anti-microbial and anti-inflammatory activity. Chalcone derivative was synthesized by Claisen Schmidt condensation between acetophenone and substituted benzaldehyde. It was refluxed with hydrazine hydrate to form pyrazole ring which on reaction with substituted benzoyl chloride in acetone and triethylamine to form to get the parent compound from which the final derivatives has been synthesized. The structures of newly synthesized compounds so obtained were confirmed by using IR, HNMR, MS spectral data.