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Detection of Cefepime Resistance Gram Negative Bacteria among Clinical Isolates from Khartoum State Hospitals during July to September at 2018

Mahadi Hassan Abdalla*, Ali Mohmed Ali, Omer Altahir Babiker, Mohmed Merghani Mahmood, Orwa Mohammed awad

Introduction: The Gram negative bacteria is leading cause of Varity of infectious e.g. Urinary Tract Infection, Gastro Intestinal Tract infections, dysentery, wound infections, septicemia, bacteremia, and meningitis. Majors organisms contributed for these infections, are E.coli, Klebsiella spp., Proteus, Salmonella, Shigella, Enterobacter and Citrobacter.

Methods: Across sectional study was conducted in Khartoum state hospitals during the period from July to September 2018. 200 clinical isolates of gram negative were collected and identified base on standard microbiological methods, cefepime susceptibility testing was done for detection of cefepime resistant using disc diffusion method.

Result: 200 clinical isolate samples were involved in this study 80 (40%) were male while 120 (60%) were female, common clinical isolates identified as Escherichia coli 114 (57%), proteus 39 (19.5%) klebsiella 33 (16.5%), and pseudomonas 14 (7%). Cefepime resistant isolates were 53 (26.5%), cefepime resistant bacteria commonly detected were pseudomonas aeruginosa (57.1%) followed by klebsiella pneumonia (36.4%), less common by proteus (23.7%) and rarely we detect E.coli (21%).

Conclusion: This study conducted that there is more gram negative bacteria resist cefepime, Pseudomonas aeruginosa were found the most commonly isolate cefepime resistant, correlation of age group the isolates were significant in elderly patient show more resistant than young, there is no significant or correlation of gender cefepime resistant isolate.