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Development and In-vitro Evaluation of Mucoadhesive Buccal Patches of Sertraline HCL

Rama devi Bhimavarapu, Dr.Srinath Nissankararao, V. Swamynath vaidya, S. Sandhyasree, M. Swapna shamili, B. Rukhmini devi

In the present study, an attempt was made to formulate mucoadhesive buccal patches of antidepressant drug Sertraline hydrochloride inorder to bypass the first pass metabolism. Buccal patches were prepared by solvent casting technique using polymers like Eudragit and HPMC E15LV.The prepared patches were evaluated for their weight variation, thickness, folding endurance, surface pH, swelling index, moisture uptake study, moisture absorbance study, drug content uniformity and in- vitro drug release and FTIR studies were conducted for Drug – Excipient compatibility testing. The optimized patches showed that the drug release indicates non- fickian release kinetics and diffusion as chain relaxation mechanism. Formulation F3 showed the highest release rate of 83.412% and concluded that all the prepared patches were effective and showed excellent sustained drug release.