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Differentiation between Smoking and Non-Smoking Tobacco with Pancreatic Cancer

Antonella Floree

Among the most serious risk factors for pancreatic cancer is smoking. People who smoke have roughly twice the risk of developing pancreatic cancer as those who have never smoked. Cigarette smoking is thought to be responsible for approximately 25% of pancreatic cancers. Cigarette smokers have roughly twice the risk of developing pancreatic cancer as those who have never smoked. Cigarette smoking is thought to be responsible for approximately 25% of pancreatic cancers. Cigar smoking and the use of smokeless tobacco products raise the risk as well.

Accumulating evidence suggests that carcinogenic compounds in cigarette smoke promote pancreatic cancer progression by inducing inflammation and fibrosis that also act in concert with biological factors to inhibit cell death and stimulate proliferation, thereby promoting PDAC.