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Effect of Permeation Enhancers on Diffusion of Lamotrigine Drug through Cellophane Membrane

Vinay Rao, M.Kalyan Raj, S.Ravinder, K.Sowmya, K.Praveen Kumar, M.Sudhakar

The effect of 3 different categories of permeation enhancers on the in vitro permeation of Lamotrigine across cellophane membrane were evaluated using vertical type Franz Diffusion Cell. This work was conducted as a permeation enhancer screening study for development of Lamotrigine Transdermal Drug Delivery System. Dimethyl Sulfoxide (DMSO) at 5% v/v and Tween 80 at 0.1% v/v gave a 6 and 7 folds enhancement in permeation values respectively. SLS and Peppermint Oil did not show any enhancement in the penetration.