Европейский журнал экспериментальной биологии Открытый доступ

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Effect of short-term garlic supplementation on DNA damage after exhaustive exercise in non-athlete men

Hassan Farhadi, Marefat Siakuhian, Homayun Dolatkhah, Soheila Rahimifardin and Sorayya Nariman Pour Salemi

This study was performed to determine Effect of short-term garlic supplementation on DNA damage after exhaustive exercise in non-athlete men. Twenty male non-athletes (aged 21.05±1.35 years, weigth 67.15±7.30 kg and heigth 179.2±6.92 cm and BMI 22.02±2.95 kg/m²) in a randomized and double-blind design were allocated in two equal supplement and placebo groups (700mg/day garlic or dextrose for 14 days). After supplementation, all participants were participated in bruce test. The blood samples were taken in three phases (before and after the supplementation and after the exercise). The normal data (Mean ± SD) were analyzed by repeated measure ANOVA, Tukey and independent t-test (P≤0.05). The results showed that a 14-day garlic supplementation hadn’t significant effect on 8- oxodG (P›0.05). Moreover, exercise-induced decrease of 8-oxodG in the supplement group were significantly more in comparison with those in the placebo group (P<0.05). Result of the study indicates that 14-day garlic supplementation can effected DNA damage. However, according to few studies conducted in this area, more research is needed.