Muhammad Ameen
The enlargement of the thyroid gland is a common problem in clinical practice associated with iodine deficiency, increase in serum Thyroid-Stimulating Hormone (TSH) level, natural goitrogens, smoking, and lack of selenium and iron. Diffuse goiter is characterized by the enlargement of whole thyroid gland at the age of puberty. It is observed in the patients either having hypothyroidism or hyperthyroidism or have abnormal TSH concentrations. It has investigated that Diffuse goiter has been exhibiting equivalence with diffuse radioactive iodine uptake. The data comprised of 144 patients of diffuse goiter evaluated through various statistical techniques in order to investigate various thyroid dysfunctioning based on the normal concentration of thyroid function tests. Hypothyroidism and hyperthyroidism can be accurately diagnosed with laboratory tests performed at NORI. The data along with detailed history was collected with the help of clinicians in NORI and entered in the Performa. The diagnostic evaluation relating to functional and morphological characterization has examined through serum TSH concentration and imaging. The result shows non-significant difference between hypothyroid and hyperthyroid patients of diffuse goiter and control group individuals. The study has concluded that the prevalence of diffuse goiter is not dependent on the higher and lower concentration of TSH.
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