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Оценка мукоадгезивных свойств различных полимеров и слизистых тканей с помощью анализатора текстуры

Фатманур Тугчу-Демироз

Mucoadhesive polymers are a gathering of materials utilized in various pharmaceutical frameworks. They are characterized as hydrophilic macromolecules, which contain various practical natural gatherings ready to build up associations with mucosal films. These polymers can be characterized by their communications with the mucosa. Non-covalent bonds accepted to improve mucoadhesion incorporate hydrogen-holding, hydrophobic cooperations, and electrostatic connections. Mucoadhesive polymers might be cationic, anionic, or non-ionic. Anionic polymers, for example, poly(acrylic corrosive) derivates, are accepted to frame hydrogen bonds beneath their pKa between their carboxylic gatherings and the hydroxyl gatherings of the bodily fluid glycoprotein. It has additionally been recommended that particle dipole communications may happen when in the carboxylate. Also, poly derivates might be joined in arrangement with thermoresponsive polymers, as poloxamer 407 (P407), to upgrade maintenance. Thermoresponsive polymers change from a fluid to a gooey gel over a basic temperature, taking into consideration section through an utensil before thickening upon application to the body. The component of mucoadhesion is commonly separated into two stages: the contact stage and the union stage. The principal stage is described by the contact between the mucoadhesive and the bodily fluid film, with spreading and expanding of the definition, starting its profound contact with the bodily fluid layer. In the union advance, the mucoadhesive materials are enacted by the nearness of dampness. Dampness plasticizes the framework, permitting the mucoadhesive particles to split free and to connect up by frail vander Waals and hydrogen bonds. Mucosal surfaces spread the nasal, visual, buccal, rectal, vaginal, and gastrointestinal zones among different pieces of the body. Medications might be directed to these destinations for nearby impact, and their high porousness makes them appealing for fundamental medication conveyance. Be that as it may, the regular freedom instruments from these destinations limit living arrangement time, diminishing medication assimilation or span of neighborhood impact. So as to beat these weaknesses, "mucoadhesive" frameworks have been created, which hold fast to mucosal films through an assortment of alluring physicochemical associations, improving maintenance, and in this manner the adequacy of medications Mucoadhesion is the capacity of materials to stick to mucosal layers in the human body and give a transitory maintenance. This property has been broadly used to create polymeric dose structures for buccal, oral, nasal, visual and vaginal medication conveyance. Incredible mucoadhesive properties are run of the mill for hydrophilic polymers having charged gatherings and additionally non�ionic utilitarian gatherings fit for shaping hydrogen bonds with mucosal surfaces. This component article thinks about late advances in the investigation of mucoadhesion and mucoadhesive polymers. It gives a diagram on the structure of mucosal films, properties of bodily fluid gels and the idea of mucoadhesion. Essential destinations behind the utilization of mucoadhesive medication conveyance gadgets are to delay their private time at the specific site to make them target explicit, and to improve the medication ingestion process. Along these lines, the estimation of mucoadhesivity is a critical advance to plan the mucoadhesive medication conveyance frameworks. The procedure of the utilization of mucoadhesive polymeric materials to improve the adequacy of remedial medicines has been presented as some time in the past and the methodology is still of an extraordinary enthusiasm for the field of pharmaceutical sciences. In vitro or ex vivo procedures are significant in the exhibition testing of mucoadhesive medication conveyance frameworks and are savvy in choosing proficient frameworks when contrasted and in vivo strategies. These techniques can assess mucoadhesive details, without utilizing creature models, and may offer robotic comprehension of mucoadhesion. Various strategies have been created to survey and comprehend the mucoadhesion of medication conveyance frameworks. The advancement of new strategies ought to be approved by correlation with a highest quality level in vitro method, or in vivo execution. New strategies to examine the mucoadhesive profile of semisolid polymer frameworks are commonly evolved in-house on bespoke hardware, and have not experienced approval, which stresses the significance of normalized methods. Besides, every measurements structure may require diverse trial conditions and examination may just be conceivable inside dose structure types. The separation power technique (otherwise called the ductile strategy) is the most broadly utilized technique to explore glue associations between a mucosal film (or other substrate) and a detailing. This strategy can be utilized for strong and semisolid measurement structures and it is realized that instrumental boundaries and analysis configuration impact test results. Different strategies, for example, the rheological strategy, can bring about various reactions and translations relying upon the examination type utilized. In this way, it is imperative to comprehend the factors of the technique for mucoadhesion testing, taking into account that normalized strategies have been required.

Мукоадгезия — это ошеломляющий процесс, и были предложены различные предположения для уточнения рассматриваемых инструментов. Это гипотеза смачивания, гипотеза диффузии, гипотеза перелома, электронная гипотеза, гипотеза адсорбции. Мукоадгезионные транспортные структуры исследуются для ограничения динамических специалистов определенной областью/местом. Полимеры взяли на себя значительную работу по структурированию таких структур, чтобы построить время обитания динамического специалиста в идеальной области. Мукоадгезионные полимеры являются водорастворимыми и нерастворимыми в воде полимерами. Мукоадгезионные полимеры, которые прочно удерживаются на муциновой эпителиальной поверхности, можно полезно разделить на три обширных класса:

1. Полимеры, которые становятся липкими при затвердевании в воде и обязаны своей мукоадгезией вязкости.

2. Полимеры, которые образуются путем неопределенных, нековалентных связей, по своей природе являются электростатическими.

3. Полимеры, которые затрудняют определение рецепторного участка на собственной поверхности.

Каждый из трех типов полимеров может быть использован для транспортировки лекарств. В рамках этого исследования были разрешены мукоадгезионные свойства определений геля, которые были созданы с различными полимерами, для различных слизистых тканей. В качестве полимеров были использованы восемь различных полимеров; Kitosan M, Kitosan H, HPMC K15M, HPMC K100M, гуаровая камедь H, гуаровая камедь S, Carbopol® 974 P и Policarbophil® AA-1. Для исследований мукоадгезии гелей были использованы девять различных слизистых тканей, подобных бычьим (вагинальная, носовая, буккальная, кишечная, толстая кишка, желудок, матка и горло). TA.XT. Кроме того, Texture Analyzer использовался для оценки способности определений мукоадгезива геля отделяться от слизистой оболочки и процедуры мукоадгезии. Более того, липосома как каркас микрочастиц была добавлена ​​к деталям геля, чтобы посмотреть, как это повлияло на связь. В свете общих результатов Kitosan H и Guar Gum H были рассмотрены как лучшие мукоадгезионные свойства по сравнению с другими полимерами