Европейский журнал экспериментальной биологии Открытый доступ

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Evaluation the role of peripheral histamine receptors (H1 and H2) in food and water intake in broiler chickens with satiation condition

Javad Cheraghi, Ehsan Hosseini, Zahra Shamsi Biranvand,Kamran Taherpour, Kianush Zarrin Kaviani and Leila Rezazadeh

Histamine H1 and H2 receptors (H1-Rs) are found in peripheral tissues and in regions of the hypothalamus that are concerned with regulating body composition. This study was designed to evaluate the role of peripheral Histamine receptors (H1 and H2) in food and water intake in broiler chickens with satiation condition. Thirty –two broiler chickens weighing 700±50 gr were randomly divided in four groups (each group comprises 8 broilers) as groups: 1- Chlorpheniramine (Antagonist H1), 2- Phamotidine (Antagonist H2), 3-Histamine (Histamine-Dihydrochloride), 4- Control (Distilled water). Each broiler was individually put in separate metabolic cage for measurement of food and water intake. The animals were exposed to continuous light and the temperature of the first week of husbandry was ranged in 31-320C and then the temperature were decreased 2-3°C every week so that in the time of experiment the temperature reached to 21-240C.In this period food and water were supplied in adlibitum. Our research indicates that Chlorpheniramine (Antagonist H1), Phamotidine (Antagonist H2) and Histamine-Dihydrochloride decreased food intake in most time bouts after injection compared to control group (p<0.0001). Also the result showed that Chlorpheniramine (Antagonist H1) decreased water drink (gr) in 180 min , 240 min, 300 min, 360 min, 420 min ,480 min , 540 min, 600 min, 660 min , 720 min, after injection compared to control group (p<0.0001) .Phamotidine (Antagonist H2) caused falling in water consumption in 360 min, 420 min, 480 min, 540 min, 600 min, 660 min, 720 min, 1260 min and 1380 min after the injection. (p<0.0001).