Журнал аутакоидов Открытый доступ

Абстрактный

Female Gender and Hispanic Ethnicity are Associated with Increased Risk of Subacute Methotrexate Encephalopathy

Dahl GV

Subacute immune suppressant drug (MTX) nervous disorder is poorly understood. we have a tendency to performed a historical cohort study of all cases of acute MTX nervous disorder at Lucile Packard Children’s Hospital from January one, 2005, to day, 2011. Of 272 patients receiving MTX, twenty one patients were diagnosed with acute MTX nervous disorder. 9 patients (42.9%) during this study were Hispanic females, whereas Hispanic females pictured fifty six of 272 (20.6%) total patients (p=0.0084). more comparison with the 2010 Golden State census confirms a Hispanic feminine predominance (p=0.032). we have a tendency to report a predominance of Hispanic females with acute MTX nervous disorder, that suggests a genetic polymorphism that will increase sickness risk.