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Formulation and Development of Diltiazem HCL Controlled Released Microcapsules by Ionotropic Gelation Technique

Praveen Kumar Uppala, Madhusha Reddy.Y, Murali Krishna.B, Chakravarthi.G, Ashok Reddy.P

The aim of the present study was to prepare and evaluate microcapsules of Diltiazem Hydrochloride using blend of Sodium CMC and Xanthan Gum by Ionotropic Gelation technique for controlled release. Microscopic analysis data indicated that the prepared microcapsules were in the ranges of 1009 to 1311μm. SEM photographs confirm the prepared formulations are spherical in nature. DSC studies and FT IR spectra showed that the encapsulated drug was stable in the prepared formulations. The prepared formulations were analyzed quantitatively for the amount of encapsulated drug. From the drug loading, encapsulation efficiency and in vitro drug release data, optimum formulation F7 was selected. The optimum formulation shows the drug release of 84.04% up to 12 h having drug loading and encapsulation efficiency of 18.24 mg and 91.20% respectively. It was also observed that, there was no significant release of drug at gastric pH. The release kinetics for all the formulations indicated that drug release followed non -Fickian diffusion. The optimized formulation was selected for stability studies. The release performance was greatly affected by the ratio of materials used in preparation of microparticles. Diltiazem Hydrochloride loaded microcapsules have desirable release profiles and worthy of further investigation as an oral controlled release dosage form.