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It is all in your gut - novel links between gut hormones and obesity, metabolic diseases, inflammation, malignancies and reproductive system

Nevena Ilic Korea

The epithelial duct is associate degree organ essential for the digestion and extraction of nutrients, however it’s conjointly body’s largest endocrine organ. 1st discovered hormones at the start of the twentieth century were endocrine, hormone and cholecystokinin. Now, we tend to discuss concerning quite thirty completely different restrictive amide hormones and quite ten styles of endocrine cells found in abdomen, little and huge intestines, like incretins (glucose-dependent insulinotropic amide and glucagon-like peptide-1), peptide YY, oxyntomodulin, ghrelin, obestatin et al.. The role of gut hormones in energy physiological state has been studied over the past twenty years. a good deal of researches in last years had shown the link between channel hormones, fat and sort two polygenic disorder, beginning with incretin thought. Now, we've got therapies supported gut hormones as targets, for patients with fat, polygenic disorder and non alcoholic liver disease. Latest knowledge gift gut peptides as novel regulators of enteral conjugated protein secretion and therefore could have a good role in vessel risk. Studies confirmed that gut hormones play a crucial role within the regulation of metabolic, water and salt physiological state and therefore the development of high blood pressure and vessel diseases. Recent investigations explained molecular mechanisms connecting gut hormones, hormone resistance and malignancies furthermore as inflammation processes in organism. Gut-brain axis and metabolism in polycystic ovary syndrome and it’s treatment has been an issue of polemics on recent medicine debates.