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Lobular Breast Cancer and Abdominal Metastasis: What Is The Correct Diagnostic Management?

Invento A, Rossi EMC, Grigolato D and Pellini F

Invasive lobular breast cancer represents the second most prevalent histological type of breast cancer after invasive ductal cancer (IDC) and its incidence has been constantly growing in the last few years. This trend is largely related to the use of MR as a radiological diagnostic method of second level. We have analyzed our institutional case and the use FDG CT/PET in this case. FDG CT/PET demonstrates lower SUV and less accuracy both in primary as well as in metastastic ILC compared to IDC. Moreover, the patterns of metastatic spread differ between ILC and IDC. We think that for this type of cancer could be use CT-PET with a particular metabolite: 1 [¹⁸F]-Fluoroestradiol (¹⁸F-FES-PET). ¹⁸F-FES-PET has the potential to assess heterogeneity in ER expression that are expressed in lobular breast cancer.