Тенденции в зеленой химии Открытый доступ

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Nanosponges in Drug Delivery

KR.Ranga Reddy1, Dr. K. V. Sastry1, Dr. V. Uma Maheshwara Rao1

Nanosponges are porous polymeric delivery systems that are tiny spherical particles which contain nanometer sized cavities with high porous surface, in which a variety of drugs can be encapsulated and improve the solubility of poorly water soluble drugs. These particles have capacity of carrying both hydrophilic and lipophilic drugs[1]. Theyforma suspension when dispersed in water, thereby forming a matrix-like structure in aqueous media, allowing a free transfer of entrapped drug molecules and prolong the drug release. These have aproperty of forming a sponge-like structure and have high capacity to entrap small molecules in its matrix.The total solubility effect exerted by Nanosponges may be because of entrapment in the matrix as well as the formation of inclusion complex with drug.Therefore, Nanosponges can form both inclusion and non-inclusion complexes. The ability of these to form non-inclusion complexes with drug molecules may be because they are consisting of more than one cyclodextrin units closely associated with each other[2].