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Pathogenesis of SARS-CoV-2 and its Variants

Murtaza Bohra, Uma Rani, N Murugan*

COVID-19 is a major health concern globally. The virus found to have zoonotic transmission with latency period of the virus is 2-14 days. These viruses majorly infect the type 2 pneumocystis in the alveoli of lungs by binding to the Angiotensin Converting Enzyme 2 (ACE-2) with the help of spike proteins. The virus divides and replicates using host organism’s replication machinery and get released into the surrounding cells by exocytosis. In response to the virus, the host body release inflammatory mediators which results in cytokine storm and leads to high fever and impaired oxygenation.