Журнал интервенционной кардиологии Открытый доступ

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Role of CaMKII in CaMKII/[Na+]i/[Ca2+] i Feedback in Myocardial Ischemia and Reperfusion Injury: A Simulation Study

Juan Yu, Minzhou Zhang and Jianyong Qi

Myocardial ischemia and reperfusion injury (MIRI) is a serious complication after percutaneous coronary intervention, which leads to heart failure, increased infarction size, and severe arrhythmias. Various signaling pathways were found to be participated in the process of MIRI, such as phosphatidylinositol 3-kinase (PI3K)/AKT, extracellular signal-regulated kinase (ERK), endothelial NO synthase (eNOS), etc