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Synthesis of Substituted 7-Methyl-2,8-Dihydropyrazolo[1,5-α][1,3,5]-Triazine Derivatives for Anti-Inflammatory and Anti- Microbial Screening

Niraj V. Patel and Dr. Dhrubo Jyoti Sen

A series of condensed pyrazolo and triazine derivatives have been synthesized to their physical property melting point, % yield, retention factor (Rf) have been evaluated. Structure is confirmed by UV, IR, NMR and Mass. All synthesized compounds are screened for two biological activities (Anti-inflammatory and Anti-microbial). Anti-inflammatory activity has been carried out by rat paw edema method while anti-microbial activity has been carried out by filter paper disc method. MIC (minimum inhibitory concentration) for antimicrobial screening has been carried out by tube dilution method.