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The Role of Personality Functioning in Treatment Outcomes during the Long-Term Treatment with Atypical Antipsychotics in Stable Schizophrenia Patients

Margarita A Morozova

Schizophrenia is a complex neurobehavioral disorder for which there are many promising new treatments. Although most attention was previously paid to psychopathology, current outcome parameters such as cognitive and occupational performance, emotional stability, quality of life and psychosocial functioning are recognized as important determinants of treatment success. In this study, the long-term course of remission was observed in 130 schizophrenia patients with good response to atypical antipsychotics. The impact of the level of personality functioning on treatment outcomes in the long-term observation was described. The definition of personality functioning was given. Conclusions: the level of personality functioning significantly affects the treatment outcomes as the patients with different levels showed the substantial difference in treatment outcomes even if their diagnoses, stages of illness at the beginning of the observation and treatment modalities were similar, with good treatment response (at least absence of relapse) and tolerability.