Американский журнал передовой доставки лекарств Открытый доступ

Абстрактный

Viscometric Studies of N-(3-Substituted) Phenyl-4-Methoxy Phenyl Schiff’s Bases in Water-dioxane Mixture at Various Percentage Compositions

Ruhi A. Khan

Recently the viscometric measurements of N-phenyl-4- methoxyphenyl Schiff’s base (PMPSB) and N-(3-nitro)phenyl-4- methoxyphenyl Schiff’s base (NPMPSB) were carried out at different percentage compositions of dioxane-water solvent to investigate the solute-solvent interactions of drugs with mixture of solvent and the effect of dilution of the solvents. It is clear from the study that bulky substituent on the molecule is not only factor which affect trend of relative viscosity but electron donating nature, electron clouds, nature of hetero atom present in drugs and the compactness in the molecule will directly hampered results and trends in the relative viscosity. These properties are directly related with viscosity measurements. Absorption, transmission, metabolism and excretion are also depending on viscosity. Predication of these factors can be done by viscometric measurementsThe effects of various substituents were also investigated.