Copper therapy is aimed at removing excess accumulated copper and preventing its reaccumulation. Copper overload results in Wilson disease. Chelation therapy drugs approved for treating Wilson disease include penicillamine (Cuprimine® and Depen®) and trientine (Syprine® and Trientine Dihydrochloride) both of these drugs act by chelation or binding of copper, causing its increased urinary excretion.