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Opioids, Substance P and Some Other Delicate Neurochemical Regulators of Body Weight and Appetite

Vardanyan GS, Shaljyan AL, Saharyan AV, Aghajanov MI

Obesity is one of the biggest challenges in the modern world. It is an established risk factor in the development of a variety of metabolic conditions such as metabolic syndrome, diabetes mellitus, cardiovascular diseases and others. By its nature obesity is heterogeneous condition and a wide range of factors are included in its etiology. It has specific neurobiological base in which the system of rewards has an important biological role. In recent years growing body of literature demonstrated neurobiological and behavioral relationships between food intake, drug addiction and withdrawal syndrome.